Table 5.
Cluster of QRC-PCOS PPI network.
| Cluster | Score | Nodes | Edges | Genes |
|---|---|---|---|---|
| 1 | 37.628 | 44 | 809 | KDR, APOE, AR, MAPK14, STAT1, CCL2, HMOX1, FLT1, INS, TIMP1, IGF1, MMP9, CD36, JAK2, KNG1, TNF, STAT3, EDN1, ESR1, F2, CDKN1A, GAPDH, HSP90AA1, ALB, IL6, FGF2, SERPINE1, VCAM1, VWF, VEGFA, IL10, IL1B, MMP2, NOS3, IGF1R, HRAS, AGT, PPARA, ICAM1, TGFB1, PPARG, MMP1, SRC, EGFR |
| 2 | 10.738 | 66 | 349 | F13A1, LHCGR, FGFR1, CNR1, CDK2, NAMPT, TGFB3, PDPK1, IL17A, DRD2, COG2, INSR, SHBG, PTPN1, EDNRB, CASR, IRS2, HDAC3, ESR2, KISS1, CA2, ABL1, DRD3, ERBB4, GNRHR, HSD17B6, NPY, NOS2, PIK3R1, ADIPOR1, IL1A, VDR, SERPINF2, APLN, GSK3B, CYP19A1, PTH, IGFBP1, SREBF1, SAA1, GNAS, ADRB3, GHR, MTNR1A, ADRA2B, POMC, CCK, ATIC, NGF, IGF2, C3, HCRT, EDN2, GNAQ, ADM, SERPINA1, IGFBP2, PYY, PIK3CG, STK11, APOA1, EGF, F5, MTNR1B, ADRB2, HMGCR |
| 3 | 10.432 | 38 | 193 | GGT1, LPL, RAC1, BAX, AKT1, HSPB1, RETN, MIF, LEP, ADIPOQ, TIMP2, ACE, BDNF, YAP1, UCP2, IRS1, TNFRSF11B, SPP1, MMP3, MET, TEK, AKT2, REN, SMAD4, LCK, PGR, SLC2A4, PTPN11, APOB, KIT, FOXO1, IL18, IGFBP3, PGF, XIAP, GRB2, IL2, SOCS3 |
| 4 | 5.698 | 54 | 151 | MAP2K1, SERPINC1, GCG, CD40LG, ELANE, NR5A1, AGTR1, MME, PNPLA2, TH, HCK, CD4, CDK5, CDK6, CASP1, SYK, ESRRG, IAPP, ATM, CASP3, PLIN1, PPARGC1A, FABP4, RARB, CRH, DPP4, RARG, SULT2A1, MMP8, MC4R, PRL, GHSR, IL5, IL6R, EIF4E, CYP11A1, GNRH1, HP, ITGB3, CTSS, CHEK1, GH1, SST, PON1, GHRL, SREBF2, PRKCZ, ZAP70, GIP, NR3C1, AVP, GAB1, THRB, LPA |
| 5 | 4.903 | 32 | 76 | Quercetin, GSTA1, EPHX1, HSD17B1, ACVR2B, INHBA, NPPA, NR1I2, AMH, INHBC, FGF19, RAP2A, HSD3B2, TTR, STAR, ENG, GSTT2, AHSG, FOXL2, PDE5A, MAPK10, CYP11B2, CYP11B1, GSTA3, INHBB, GSTM2, WNT4, GSTM3, APOA4, NR1H4, HSD3B1, ACVR2A |
| 6 | 4.75 | 33 | 77 | SRD5A1, RXRA, GHRH, RARA, GSR, MGAM, KCNJ11, NRIP1, ACHE, PCK1, APAF1, CDKAL1, NR1H3, FST, CYP17A1, GDF9, CHGA, FSHR, CAPN10, Resveratrol, FTO, FAS, GAL, TCF7L2, HSP90B1, HHEX, NCOA3, INSL3, SLC30A8, APOA2, PRKACA, NCOR1, PPARD |
| 7 | 3 | 5 | 6 | FSHB, INHA, ACVR1, AMHR2, CGA |
| 8 | 3 | 3 | 3 | RAB9A, PLIN3, PGRMC1 |
| 9 | 3 | 3 | 3 | GYS1, PPP1CC, PPP1R3A |
| 10 | 2.667 | 4 | 4 | CYP2D6, CYP1B1, GSTP1, HPGDS |