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. 2019 Dec 5;9:18445. doi: 10.1038/s41598-019-54585-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Renal inflammation during recovery phase of young and aged mice. (A) In immunohistochemical staining, infiltration of F4/80⁺ macrophages increased during recovery phase in both young and aged mice and remained for a significantly longer duration in aged mice than in young mice, (B) Prior to IRI, the renal expression of TNF-α, IFN-γ, and IL-12 was higher in aged mice than in young mice, suggesting the presence of low-grade inflammation. After IRI, they were increased more in aged mice than in young mice and the difference was greater on day 28, (C) The number of neutrophils was also significantly higher in aged kidneys. Magnification: ×100, *p < 0.05 compared to young mice, n = 4–6 per group.