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. 2019 Dec 5;9:18423. doi: 10.1038/s41598-019-54878-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of IL-33–induced mast cell activation by resveratrol. (A,B) ELISA of IL-6, IL-13, and TNF-α in culture supernatants of BMMCs (A) and FSMCs (B) treated with resveratrol and exposed to 1 ng/ml rmIL-33 for 6 h (n = 3). (C) ELISA of IL-13 in human peripheral blood basophils treated with resveratrol and exposed to rhIL-33 for 6 h in the presence of rhIL-3 (n = 3). (D) Mice were orally treated with resveratrol for 2 h, and then challenged with intranasal administration of 1 μg IL-33 for 24 h. mRNA expression of IL-6 and IL-13 in the airway was determined by qPCR (n = 4–6). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.