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. 2019 Dec 5;10(12):930. doi: 10.1038/s41419-019-2171-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic representation of the genomic organization of ZNF667-AS1 and ZNF667. b Relative expression of ZNF667-AS1 and ZNF667 in various tumor types in GEPIA data set. ACC adrenocortical carcinoma, BLCA bladder urothelial carcinoma, BRCA breast invasive carcinoma, CESC Cervical squamous cell carcinoma and endocervical adenocarcinoma, CHOL cholangio carcinoma, COAD colon adenocarcinoma, DLBC lymphoid neoplasm diffuse large B-cell lymphoma, ESCA esophageal carcinoma, GBM glioblastoma multiforme, HNSC head and neck squamous cell carcinoma, KICH kidney chromophobe, KIRC kidney renal clear cell carcinoma, KIRP kidney renal papillary cell carcinoma, LAML acute myeloid leukemia, LGG brain lower grade glioma, LIHC liver hepatocellular carcinoma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, OV ovarian serous cystadenocarcinoma, PAAD pancreatic adenocarcinoma, PCPG pheochromocytoma and paraganglioma, PRAD prostate adenocarcinoma, READ rectum adenocarcinoma, SARC sarcoma, SKCM skin cutaneous melanoma, STAD stomach adenocarcinoma, TGCT testicular germ cell tumors, THCA thyroid carcinoma, THYM thymoma, UCEC uterine corpus endometrial carcinoma, UCS uterine carcinosarcoma. c Relative expression level of ZNF667-AS1 and ZNF667 in human normal esophageal epithelial cells HEEpiC and four esophageal cancer cell lines detected by qRT-PCR method. d Relative expression level of ZNF667-AS1 and ZNF667 in ESCC tissues and corresponding normal tissues. e Relative expression level of ZNF667-AS1 and ZNF667 in different subgroups. f The correlation between the expression level of ZNF667-AS1 and ZNF667 in ESCA in GEPIA data set. g The correlation between the expression level of ZNF667-AS1 and ZNF667 in ESCC tissues. h The influence of expression level of ZNF667-AS1 or ZNF667 on ESCC patients’ survival. *P < 0.05.