Fig. 7. Cell cycle state in Meta4 cells treated with either DMSO or Selumetinib.

a Heatmap of cell cycle genes categorized by phase in DMSO vehicle-treated and Selumetinib-treated Meta4 samples. Rows correspond to individual genes and columns are individual cells, arranged by sample and matched subpopulations. Yellow corresponds to high expression, gray corresponds to neither high nor low expression, and black corresponds to low expression. b Dot plots showing cell cycle meta-genes for each cell cycle phase. Results are shown for matched subpopulations (1–4) and split by treatment (DMSO vehicle or Selumetinib). The dot size represents the percent of cells within the matched subpopulation with detected expression of the gene and color intensity reflects the average expression in those cells with detectable gene expression.