Table 1.
Snake venom CRAMPs deposited in the Antimicrobial Peptide Database (APD), access to mature peptide and UniProtKB for precursor peptide.
| ID | Peptide name | Source organism | Active peptide sequence | Number of residues (aa) | Activity* | Secondary structure/method | Reference | |
|---|---|---|---|---|---|---|---|---|
| Prepro | Mature | |||||||
| AP00897/B6S2X0 | NA-CATH | Chinese cobra Naja atra |
KRFKKFFKKLKNSVKKRAKKFFKKPKVIGVTFPF | 191 | 34 | Antibacterial (G+ and G‑), antibiofilm | α-helix/NMR | (Zhao et al., 2008) (Du et al., 2015) |
| AP00896/B6D434 | BF-CATH | Banded krait Bungarus fasciatus |
KRFKKFFRKLKKSVKKRAKEFFKKPRVIGVSIPF | 191 | 34 | Antibacterial (G+ and G‑) | α-helix/NMR | (Zhao et al., 2008) |
| AP00895/B6S2X2 | OH-CATH | King cobra Ophiophagus hannah |
KRFKKFFKKLKNSVKKRAKKFFKKPRVIGVSIPF | 191 | 34 | Antibacterial (G+ and G‑), enzyme inhibitor | α-helix/NMR | (Zhao et al., 2008) |
| AP01239/B6D434 | Cathelicidin-BF | Banded krait B. fasciatus |
KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF | 191 | 30 | Antibacterial (G+ and G‑), enzyme inhibitor antifungal, antitumor |
α-helix/NMR | (Wang et al., 2008) |
| Not available/U5KJJ1 | Pt_CRAMP1 | Eastern-brown-snake Pseudonaja textilis |
KRFKKFFMKLKKSVKKRVMKFFKKPMVIGVTFPF | 184 | 34 | Antibacterial (G+ and G‑) | α-helix/NMR | (Falcao et al., 2014) |
| Not available/U5KJM6 | Pt_CRAMP2 | Eastern-brown-snake P. textilis |
KRFKKFFRKLKKSVKKRVKKFFKKPRVIGVTIPF | 184 | 34 | Antibacterial (G+ and G‑) | α-helix/NMR | (Falcao et al., 2014) |
| AP02424/U5KJM4 | Crotalicidin (Ctn) | South American rattlesnake Crotalus durissus terrificus |
KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF | 194 | 34 | Antibacterial (G+ and G‑), antifungal, antitumor | α-helix/NMR | (Falcao et al., 2014) (Falcao et al., 2015) |
| AP02423/U5KJC9 | Batroxicidin (BatxC) |
South American pit vipers Bothrops atrox |
KRFKKFFKKLKNSVKKRVKKFFRKPRVIGVTFPF | 189 | 34 | Antibacterial (G+ and G‑), antiparasitic | Unknown | (Falcao et al., 2014) |
| Associated with crotalicidin/U5KJT7 | Lutzicidin | South American pit vipers Bothrops lutzi |
KRFKKFFKKLKNNVKKRVKKFFRKPRVIGVTIPF | 189 | 34 | Antibacterial (G+ and G‑) | Unknown | (Falcao et al., 2014) |
| Associated with crotalicidin/U5KJZ2 | Lachesicidin | South American pit vipers Lachesis muta rhombeata |
KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTFPF | 194 | 34 | Antibacterial (G+ and G‑) | Unknown | (Falcao et al., 2014) |
| AP02569/A0A0G3DRW6 | Hc-CATH | Blue-banded sea snake | KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL | 187 | 30 | Antibacterial (G+ and G‑), antifungal |
α-helix/CD | (Wei et al., 2015) |
| Hydrophis cyanocinctus | ||||||||
| AP02964/A0A2P1AGD5 | CATHPb1 | Burmese python Python bivittatus |
KRFKKFFRKIKKGFRKIFKKTKIFIGGTIPI | 175 | 31 | Antibacterial (G+ and G‑), anti-MRSA and VRSA, antibiofilm, antifungal |
α-helix/CD | (Cai et al., 2018) |
| AP03077/A0A4D6DT23 | SA-CATH | Chinese snake Sinonatrix annularis |
KFFKKLKKSVKKHVKKFFKKPKVIGVSIPF | 191 | 30 | Antibacterial (G+ and G‑), antibiofilm, antifungal, anti-inflammatory | Unknown | (Wang et al., 2019) |
(*) Activity abbreviations: inhibiting both Gram-positive and Gram-negative bacteria (G+, G‑); methicillin-resistant and vancomycin-resistant S. aureus (MRSA and VRSA, respectively).