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. 2019 Dec 6;4:58. doi: 10.1038/s41392-019-0091-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — MKP-1 was decreased in AD. a, b The protein level of MKP-1 assessed by western blot in the hippocampus a and temporal cortex b of control (Ctrl) and AD patients. *p < 0.05 by unpaired Student’s t test. n = 4–6 in each group. c The protein level of MKP-1 in the hippocampus of wild-type (WT) and APP/PS1 transgenic AD model mice at the age of 9 months. ***p < 0.001 by unpaired Student’s t test. n = 6 in each group. d The protein level of MKP-1 in the hippocampus of AD mice at different ages. ***p < 0.001 by one-way ANOVA. n = 3 in each group. e, f The protein levels of APP e and MKP-1 f assessed by western blot in lysates of N2A and N2A^APP cells. ***p < 0.001 by unpaired Student’s t test. n = 3–6 in each group.