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. 2019 Dec 6;4:58. doi: 10.1038/s41392-019-0091-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — MKP-1 reduced Aβ generation and senile plaque numbers in APP/PS1 mice. a–c Immunoblot of the expression of MKP-1 b and P-ERK c in the hippocampal homogenates of wild-type (WT) and APP/PS1 transgenic AD mice after overexpression of MKP-1 by AAV_MKP-1 or knockdown of MKP-1 by AAV_shMKP-1. *p < 0.05, **p < 0.01 and ***p < 0.001 by one-way ANOVA. n = 4–5 in each group. d, e The number of senile plaques detected by immunohistochemistry in the hippocampus of AD model mice after overexpression of MKP-1 by AAV_MKP-1 or knockdown of MKP-1 by AAV_shMKP-1. *p < 0.05 and ***p < 0.001 by one-way ANOVA. n = 29 to 54 in each group. f, g Generation of Aβ₄₀ f and Aβ₄₂ g as measured by ELISA in the hippocampal homogenates of WT and AD model mice after overexpression of MKP-1 by AAV_MKP-1 or knockdown of MKP-1 by AAV_shMKP-1. *p < 0.05, **p < 0.01, and ***p < 0.001 by one-way ANOVA. n = 5 in each group. h–l Immunoblot of the expression of APP i, C89 j, C99 k and BACE1 l in the hippocampal homogenates of WT and AD mice after overexpression of MKP-1 by AAV_MKP-1 or knockdown of MKP-1 by AAV_shMKP-1. *p < 0.05 and **p < 0.01 by one-way ANOVA. n = 5 in each group.