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. 2019 Dec 5;10(12):932. doi: 10.1038/s41419-019-2161-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The scratch test was used to detect the migration ability of HUVECs, and photographs were taken at 0 and 24 h after adding the conditioned medium from BMSCs transfected with lentivirus Lenti-hsa_circ_0074834 or pLKO.1-hsa_circ_0074834 and control plasmid. Scale bar 500 μm. b Transwell test was used to detect the invasion ability of HUVECs, and photographs were taken at 24 h after adding the conditioned medium from BMSCs transfected with lentivirus Lenti-hsa_circ_0074834 or pLKO.1-hsa_circ_0074834 and the control plasmid in the down chamber. Scale bar 100 μm. c Tube formation analysis of angiogenesis of HUVECs and e quantitative analysis. Scale bar 100 μm. d ELISA analysis of the secretion of VEGF, Endostatin, PAI-1 and Thrombospondin-1 in the culture medium of BMSCs transfected with lentivirus Lenti-hsa_circ_0074834 or pLKO.1-hsa_circ_0074834 and control plasmid. The results are presented as the mean ± SD. *p < 0.05, **p < 0.01.