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. 2019 Nov 29;10:1407. doi: 10.3389/fphar.2019.01407

Figure 4.

Figure 4

Phase 1 decreases in mean arterial pressure (ΔMAP) and heart rate (ΔHR) (A and B, respectively) and phase 2 hypotensive and bradycardiac effects (C and D, respectively) elicited by intravenous (i.v.) administration of 1-nitro-2-phenylethene (NPe; 3 mg/kg) in four groups of pentobarbital-anesthetized spontaneously hypertensive rats: i) Before and after bivagotomy (Biv) at cervical level, ii) before and after perineural pretreatment (PNT) of both cervical vagi with capsaicin (250 μg/ml), iii) before and after pretreatment with capsazepine (Capz; 1 mg/kg, i.v.), and iv) before and after pretreatment with ondansetron (Ond; 30 μg/kg, i.v.). Data are the mean ± SEM and expressed as a percentage of baseline (n = 6 rats per group). *P < 0.05 and # P < 0.05 by paired Student’s t test vs. the respective baseline values and the corresponding responses before any pretreatment, respectively.