Figure 7.

Maximal decreases in mean arterial pressure (MAP) (A) and heart rate (HR) (B) induced by intravenous (i.v.) injection of 1-nitro-2-phenylethene (NPe; 3 mg/kg) and trans-4-methoxy-β-nitrostyrene (T4MN; 0.3 mg/kg) in conscious, freely moving spontaneously hypertensive rats pretreated with i.v. vehicle or methylatropine (1 mg/kg). Data are expressed as the mean ± SEM and expressed as percentage of baseline (n = 5). *P < 0.001 by paired Student’s t test vs. the corresponding baseline values. ^# P < 0.001 by Mann–Whitney U test vs. corresponding responses before any pretreatment.