Table 1.
Effects of various pretreatments on basal mean arterial pressure (MAP) and heart rate (HR) in both pentobarbital-anesthetized and conscious, freely moving spontaneously hypertensive rats (SHRs) in which the cardiovascular effects of 1-nitro-2-phenylethene and trans–4–methoxy–β–nitrostyrene were investigated.
| Pretreatment | n | MAP (mmHg) | HR (bpm) | ||
|---|---|---|---|---|---|
| Basal | After T | Basal | After T | ||
| Anesthetized SHRs | |||||
| Bivagotomy | 6 | 146.0 ± 4.1 | 151.3 ± 0.8 | 315 ± 12 | 402 ± 6* |
| PNT | 6 | 142.2 ± 2.6 | 137.4 ± 1.7 | 311 ± 9 | 316 ± 8 |
| Capsazepine | 6 | 139.7 ± 4.1 | 130.2 ± 5.4 | 300 ± 16 | 303 ± 12 |
| Ondansetron | 6 | 145.9 ± 6.3 | 154.1 ± 2.7 | 309 ± 13 | 303 ± 13 |
| Intraventricular | |||||
| LV | 6 | 142.1 ± 7.3 | ————– | 304 ± 11 | ——— |
| Conscious SHRs | |||||
| Methylatropine | 5 | 170.5 ± 6 | 178.6 ± 8.7 | 321 ± 12 | 403 ± 12* |
Data are the mean ± SEM. T treatment; PNT, perineural treatment; LV, left ventricle. *P < 0.05 by paired Student’s t test.