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. 2019 May 13;47(16):8375–8387. doi: 10.1093/nar/gkz381

Figure 3.

Figure 3.

Five structural conformations of TCF4 bHLH domain. (A) In PDB 6OD3, the crystallographic unit contains four dimers exhibited in three conformations (1 to 3). (B) In PDB 6OD4, the crystallographic unit contains two dimers, with and without bound DNA. (C) In PDB 6OD5, the crystallographic unit includes two dimers bound to DNA containing the 5caC modification. (D) Superimposition of the four dimers in PDB 6OD3. (E, F) The two monomers (A and B) forming each dimer adopted dissimilar conformations. (G) Superimposition of two dimers in PDB 6OD4. (H) Superimposition of three DNA-bound conformations. (I) Superimposition of three conformations in the absence of cognate DNA.