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. 2019 Jun 14;47(16):e94. doi: 10.1093/nar/gkz536

Figure 5.

Figure 5.

Structural characteristics of CE- and CS-specific DVs. (A) Enrichment of the CE- or CS-specific DVs at PPI interfaces, the rest of surface or protein core. Residues were classified as ‘interface’ using the known interfacial sites annotated in the Interactome INSIDER (42). Residues were classified as ‘the rest of surface’ or ‘protein core’ according to the relative solvent-accessible area, using a cutoff of 10%. (B) The left and the middle panels display the proportion of the identified DVs present on interface, the rest of surface or protein core regions when using the CS or the integrated score. The panel on the right shows the fold increase in the proportion of the identified DVs by the integrated score relative to the CS score. Examples of CE-specific DVs located on PPI interfaces of cystathionine β-synthase (PDB ID: 1JBQ) (C) and platelet glycoprotein 1b alpha chain (PDB ID: 1U0N) (D).