Table 4.
Hematopoietic recovery rates on days 15, 30, 180, and 365 in the calcitriol and placebo groups of HL, NHL, and MM after autologous HSCT
| Calcitriol n† (%) |
Placebo n† (%) |
Relative risk | 95% CI | P value* | |
|---|---|---|---|---|---|
| ANC-15 ≥ 0.5 × 103/μl | 34/39 (87.2) | 37/40 (92.5) | 0.94 | 0.81 to 1.09 | 0.48 |
| ANC-30 ≥ 2.0 × 103/μl | 25/36 (69.4) | 23/40 (57.5) | 1.21 | 0.86 to 1.70 | 0.28 |
| ALC-15 ≥ 0.5 × 103/μl | 32/39 (82.1) | 17/40 (42.5) | 1.93 | 1.31 to 2.85 | <0.001 |
| ALC-30 ≥ 1.0 × 103/μl | 33/36 (91.7) | 23/40 (57.5) | 1.59 | 1.20 to 2.12 | 0.001 |
| PC-15 ≥ 20.0 × 103/μl | 24/39 (61.5) | 25/40 (62.5) | 0.98 | 0.70 to 1.39 | 0.93 |
| PC-30 ≥ 100.0 × 103/μl | 20/36 (55.6) | 18/40 (45.0) | 1.23 | 0.79 to 1.94 | 0.36 |
| PC-180 ≥ 150.0 × 103/μl‡ | 19/32 (59.4) | 21/31 (67.7) | 0.88 | 0.60 to 1.28 | 0.49 |
| PC-365 ≥ 150.0 × 103/μl‡ | 20/28 (71.4) | 20/29 (69.0) | 1.04 | 0.74 to 1.45 | 0.84 |
| WBC-180 ≥ 4.0 × 103/μl‡ | 27/32 (84.4) | 26/31 (83.9) | 1.01 | 0.81 to 1.25 | >0.99 |
| WBC-365 ≥ 4.0 × 103/μl‡ | 26/28 (92.9) | 24/29 (82.8) | 1.12 | 0.92 to 1.36 | 0.42 |
| HC-180 recovery‡ | 17/32 (53.1) | 17/31 (54.8) | 0.97 | 0.61 to 1.53 | 0.89 |
| HC-365 recovery‡ | 17/28 (60.7) | 14/29 (48.3) | 1.26 | 0.78 to 2.03 | 0.35 |
*Chi-square tests or Fisher’s exact test (if appropriate)
†Fraction of live patients who recovered by defined days. The rest failed to recover or died before scheduled dates. Additionally laboratory results of days 180 and 365 were not available for all live patients
‡Normal values were defined as: WBC: 4.0–11.0 × 103/μl; PC: 150.0–450.0 × 103/μl; HC: males: 14.0–18.0 g/dl, females: 12.0–16.0 g/dl
Abbreviations: ALC-15 absolute lymphocyte count on day 15, ALC-30 absolute lymphocyte count on day 30, ANC-15 absolute neutrophil count on day 15, ANC-30 absolute neutrophil count on day 30, CI confidence interval, HC-180 hemoglobin concentration on day 180, HC-365 hemoglobin concentration on day 365, HL Hodgkin’s lymphoma, HSCT hematopoietic stem cell transplantation, MM multiple myeloma, NHL non-Hodgkin’s lymphoma, PC-15 platelet count on day 15, PC-30 platelet count on day 30, PC-180 platelet count on day 180, PC-365 platelet count on day 365, WBC-180 white blood cell count on day 180, WBC-365 white blood cell count on day 365