Scheme 1.

A: (i) Keto form of curcumin (IUPAC Name- (1E,6E)-1, 7-bis (4-hydroxy-3methoxyphenyl) hepta-1,6-diene-3,5-dione). A(ii) Enol form of curcumin. A (iii) Ionic form of curcumin. a: 4,4′-((1E,6E)-3-hydroxy-5-oxohepta-1,6-diene-1,7diyl) bis (2methoxyphenolate) b: ((1E,6E)-1,7- bis (4-(3-chloropropoxy)-3-methoxyphenyl)-5-hydroxyhepta-1,6-dien-3-one c: (1E,6E)-5-hydroxy-1,7-bis(4-(3-idopropoxy)-3-methoxyphenyl) hepta-1,6-dien-3-one d: Mitochondria-targeted derived compound 1,7-bis{3-methoxy-4-[3-(triphenylphosphonium) propoxy]-phenyl} hepta-1,6-diene-3,5-dionedi-iodide (TPP-curcumin)