Table 5.
Comparative In-vivo Pharmacokinetic Studies data for Oleuropein and Oleuropein loaded NLC administered through IV and IN Route
| Parameter | Unit | Oleuropein | Oleuropein NLC (Insitu gel) | |
|---|---|---|---|---|
| Extra vascular administration (Plasma Concentration) | IV Administration (BrainConcentration) a | IN Administration (BrainConcentration) b | ||
| t1/2ka | Min | 0.58103772 | – | – |
| t1/2k10 | Min | 1.180639353 | 3.76978613 | 5.4347 |
| V/F | (mg)/(mg/ml) | 18.37971308 | 2.462380734 | 0.182999079 |
| CL/F | (mg)/(mg/ml)/min | 10.79063329 | 0.123951981 | 0.0595227 |
| Tmax | Hrs | 1.170245356 | – | 23 |
| Cmax | mg/ml | 0.273704196 | 2.4 | 7.300366649 |
| Css | mg/ml | – | – | 7.30445 |
| AUC 0-t | mg/ml*min | 0.926729668 | 68.07493555 | 151.790 |
| AUC 0-inf | mg/ml*min | 0.926729668 | 80.67640346 | 168.00 |
| MRT | Hrs | 2.541562777 | 19.56 | 23.15 |
Compared with control group
aP < 0.05; Compared with control group and negative control
bP < 0.05 (IV was compared with control and IN was compared with both control and negative control)