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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Neuroendocrinology. 2019 Jun 6;110(3-4):271–281. doi: 10.1159/000501337

Figure 1.

Figure 1

In the VMN, antagonizing PAC1 receptors blocks leptin-induced hypophagia, weight loss and thermogenesis. (Left) Bilateral VMN-leptin (0.025μg/0.25μl/side) significantly suppressed feeding behavior, which was blocked with pretreatment with PACAP6–38 (500 pmol/0.25μl/side). (Middle) A similar pattern of data was observed in body weight change 24-hours post microinjection. (Right) Leptin bilaterally microinjected into the VMN significantly stimulated thermogenesis for up to 20 hours compared to vehicle and PACAP6–38 pretreated animals. Data are presented ± SEM. * = P < 0.05