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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: Psychopharmacology (Berl). 2019 Jul 13;236(12):3593–3599. doi: 10.1007/s00213-019-05331-y

Fig. 1.

Fig. 1

α7 nAChR full orthosteric agonist PNU282987 blocks nicotine CPP. Mice were conditioned with either saline (s.c.) or nicotine(0.5 mg/kg) for 3 days. A robust CPP was observed in nicotine-conditioned mice pretreated with vehicle. PNU282987 (1, 3, and 9 mg/kg; s.c.) attenuated nicotine reward as measured by the CPP. Asterisk denotes p < 0.05 from vehicle-vehicle. Number sign denotes p < 0.05 from nicotine control. Each point represents the mean ± SEM of n = 8 mice per group