Fig. 4.

No effect of α7 nAChR silent agonist NS6740 on the development of nicotine CPP. Mice underwent 3 days of conditioning with either saline (s.c.) or nicotine (0.5 mg/kg). Nicotine produced a robust CPP in mice pre-treated with vehicle. The α7 silent agonist NS6740 (1 and 3 mg/kg;i.p.) did not reduce nicotine reward as measured by the CPP test at both doses tested. Asterisk denotes p < 0.05 from vehicle-vehicle. Each point represents the mean ± SEM of n = 7–10 mice per group