Fig. 5.

PNU282987 and PNU120596 did not block morphine CPP. Mice were conditioned with saline (s.c.) or morphine (10 mg/kg) for 3 days. Morphine produced a robust CPP in mice pre-treated with vehicle. The α7 full orthosteric agonist PNU282987 (9 mg/kg; s.c.) did not attenuate morphine reward as measured by the CPP. Similarly, the α7 Type II PAM PNU120596 (3 mg/kg; i.p.) did not reduce morphine reward as measured by the CPP. Asterisk denotes p < 0.05 from vehicle-vehicle. Each point represents the mean ± SEM of n = 8 mice per group