Table 5.
Event Characteristics and Outcomes in Hypoplastic Left Heart Syndrome Subjects
| HLHS Anatomy | |||||
|---|---|---|---|---|---|
| Variable | MBT shunt (N = 9) |
RVPA shunt (N = 8) |
Hybrid (N = 2) |
Cavopulmonary Anastamosis (N = 11) |
Other CHD (N = 58) |
| Average over (up to) the first 10 minutes1 | |||||
| Chest Compression Rate (/min) | 141.1 [109.7,143.1] | 119.7 [112.7,132.4] | 132.0 [121.0,143.0] | 125.3 [118.4,155.9] | 128.3 [114.0,139.6] |
| DBP (mmHg) | 25.0 [20.0,33.3] | 23.6 [22.8,27.8] | 27.3 [18.6,36.0] | 33.0 [24.0,49.1] | 28.0 [22.9,36.1] |
| DBP (mmHg) ≥ 25 for infants or ≥ 30 for children | 5 (55.6%) | 3 (37.5%) | 1 (50.0%) | 7 (63.6%) | 38 (65.5%) |
| SBP (mmHg)2 | 67.6 [49.0,74.5] | 93.9 [64.6,102.0] | 47.6 [26.2,69.0] | 68.0 [48.7,83.0] | 67.6 [55.0,90.0] |
| SBP (mmHg) ≥ 60 for infants or ≥ 80 for children3 | 6 (66.7%) | 6 (75.0%) | 1 (50.0%) | 5 (45.5%) | 31 (53.4%) |
| MAP (mmHg) | 39.2 [29.7,47.0] | 44.7 [37.5,51.4] | 34.1 [21.1,47.0] | 42.5 [34.5,67.0] | 42.9 [35.2,53.0] |
| Chest Compression Fraction | 0.86 [0.85,0.92] | 0.95 [0.87,0.96] | 0.75 [0.73,0.77] | 0.93 [0.88,0.98] | 0.90 [0.84,0.96] |
| Outcomes | |||||
| ROSC ≥ 20 min | 5 (55.6%) | 5 (62.5%) | 1 (50.0%) | 10 (90.9%) | 41 (70.7%) |
| ROC with eCPR | 4 (44.4%) | 3 (37.5%) | 1 (50.0%) | 1 (9.1%) | 15 (25.9%) |
| Survival to hospital discharge4 | 8 (88.9%) | 3 (37.5%) | 1 (50.0%) | 6 (54.5%) | 30 (51.7%) |
1
Continuous variables are summarized using median [Q1,Q3].
2
Average SBP was not significantly different between MBT shunt and RVPA shunt subjects (p=0.075, Wilcoxon rank-sum test).
3
Rate of SBP target achievement was not significantly different between MBT shunt and RVPA shunt subjects (p=1.000, Fisher’s exact test).
4
Survival to hospital discharge was significantly different between MBT shunt and RVPA shunt subjects (p=0.050, Fisher’s exact test).