Figure 2.

Effects of DOI (3 mg/kg) administered acutely (TOP) or sub-chronically (BOTTOM) on the ethanol-induced conditioned place preference (CPP). Ethanol was administered at a dose of 1.8 g/kg because this dose produced the strongest place conditioning in preliminary experiments. Acute injections occurred 30 minutes prior to the CPP test session. Sub-chronic injections were administered immediately after the four ethanol conditioning sessions. Data are expressed as a proportion of the session time of 900 seconds. All values represent the mean + SEM. ** = p < 0.01 compared to the pretest as assessed by paired t-test.