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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Psychopharmacology (Berl). 2019 Jul 15;236(12):3567–3578. doi: 10.1007/s00213-019-05328-7

Figure 5.

Figure 5.

TOP: DOI (3 mg/kg) increases the duration of the loss of the righting reflex induced by ethanol (3 g/kg) as represented by the total time taken to recover the righting response following ethanol administration expressed in minutes. MIDDLE: Time course of blood ethanol concentrations (mg/dl) following a bolus injection of a sedating dose of ethanol (3 g/kg) after pretreatment with saline or DOI (3 mg/kg). BOTTOM: Area under the curve analysis of the blood ethanol time course determined across each individual mouse. All values represent the mean + SEM. ** = p < 0.01 as assessed by paired t test.