Table 1.

PGK1-mediated tumor suppression mechanisms

Cancer types	Molecular mechanisms	Function/clinical association	References
Fibrosarcoma	Promote the angiostatin formation	Inhibit tumor angiogenesis and tumor growth	[23]
Pancreatic cancer			[23]
Hepatocellular carcinoma	-	Inhibit tumor angiogenesis	[26]
Prostate cancer	Reduce VEGF secretion; Promote the angiostatin formation	Inhibit tumor angiogenesis	[25]
Lung cancer	Inhibit COX-2 expression; Promote anti-tumor immunity in vivo	Inhibit tumor growth	[27]
	Inhibit COX-2 expression	Inhibit tumor growth	[28]
	-	Associated with prognosis of patients	[29]
	Reduce expression of uPAR	Inhibit cell proliferation and migration	[30]
HLA-A2+ colon cancer	Recognized as a tumor-associated antigen specifically by cytotoxic T lymphocytes	Enhance the killing effect of T lymphocyte on tumor	[31]
Gallbladder carcinoma	-	Associated with prognosis of patients	[32]
		Associated with prognosis of patients	[33]

Note: ‘-’ means no detailed information.