Figure 2.

RBF deficiency combined with NMBA induces esophageal tumors in rats. A. HE staining and IHC for cytokeratin were performed on rat esophageal tissues. Representative images of esophageal papilloma (R₆N) and carcinoma in situ (R₀N). Scale bars, 50 μm. B. Incidence of benign hyperplasia and esophageal intraepithelial neoplasia in Exp 1 (n = 15-18/group) and Exp 2 (n = 12-19/group). Difference in incidence were assessed by Fisher’s exact test (P < 0.05). *Means differ, P < 0.05.