Table 4.
Hazard ratios and 95% confidence intervals for the association between APOL1 risk genotype group and incident sepsis among blacks stratified by presence or absence of CKD
| APOL1 Genotype Modela | No. Events (%)b | Crude | Model 1 | Model 2 | Model 3 |
|---|---|---|---|---|---|
| CKD | |||||
| Recessive model | |||||
| 0 or 1 risk allele | 141 (6) | — | — | — | |
| 2 risk alleles | 24 (6) | 0.96 (0.62 to 1.48) | 1.01 (0.66 to 1.57) | 1.14 (0.73 to 1.79) | 1.18 (0.70 to 1.99) |
| Dominant model | |||||
| 0 risk alleles | 53 (5) | — | — | — | |
| 1 or 2 risk alleles | 112 (7) | 1.38 (0.99 to 1.91) | 1.41 (1.01 to 1.96) | 1.66 (1.16 to 2.37) | 1.73 (1.13 to 2.65) |
| Additive model | |||||
| Per variant allele copy | 165 (6) | 1.14 (0.92 to 1.42) | 1.17 (0.94 to 1.46) | 1.31 (1.04 to 1.65) | 1.34 (1.02 to 1.76) |
| No CKD | |||||
| Recessive model | |||||
| 0 or 1 risk allele | 118 (2) | — | — | — | |
| 2 risk alleles | 23 (3) | 1.41 (0.90 to 2.21) | 1.46 (0.93 to 2.28) | 1.30 (0.77 to 2.18) | 0.92 (0.45 to 1.86) |
| Dominant model | |||||
| 0 risk alleles | 48 (2) | — | — | — | |
| 1 or 2 risk alleles | 93 (2) | 1.41 (0.99 to 2.00) | 1.41 (1.00 to 2.00) | 1.30 (0.89 to 1.90) | 1.45 (0.91 to 2.31) |
| Additive model | |||||
| Per variant allele copy | 141 (2) | 1.30 (1.02 to 1.65) | 1.32 (1.04 to 1.67) | 1.23 (0.94 to 1.60) | 1.19 (0.86 to 1.65) |
Model 1: adjusted for sex, age, income, education. Model 2: Model 1+adjusted for tobacco, deep vein thrombosis, dyslipidemia, peripheral artery disease, eGFR, albumin to creatinine ratio, systolic BP, diastolic BP, prevalent comorbidities (diabetes, coronary heart disease, stroke, dyslipidemia). Model 3: Model 2+adjusted for principal components ancestry. —, reference.
a
Estimated from Cox proportional hazard models.
b
Row percentage, proportion of participants experiencing a sepsis event.