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Cartoon representation of β-catenin/T-cell factor (Tcf) PPI interface showing three hot regions. Hot region 1 (K435 and K508 of β-catenin and D16 and E17 of Tcf4), hot region 2 (K312 and K345 of β-catenin and E24 and E29 of Tcf4) and hot region 3 (F253, I256, F293, A295, and I296 of β-catenin and V44 and L48 of Tcf4). The cooperative contributions of hot spots within one hot region stabilize PPIs (Figure taken from [31]).
