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. 2019 Nov 15;11(11):6924–6937.

Figure 5.

Figure 5

Analysis of miR-181c expression in HCC and the prediction of its targeting effect on SPP1. A. Calculation of miR-181c expression through dbDEMC2 software. MiR-181c is relatively lower expressed in multiple human maligancies, including HCC. B. qRT-PCR assay indicated significantly lower expression of miR-181c in HCC cell lines compared with L02 cells (*P<0.05). C. The predicted miR-126 binding site in the wild-type SPP1 mRNA 3’-UTR (3’UTR-WT) is visulizated, and the minimum free energy hybridization of miR-181c and SPP1 mRNA 3’-UTR is calculated (Mfe: -18.4 kal/mol).