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. 2019 Nov 15;11(11):6838–6849.

Figure 4.

Figure 4

Silencing has_circRNA_403658 inhibits lactate production and LDH activity in bladder cancer cells. A. Lactate concentrations were determined in 5637 and T24 cells after 48 h transfection with has_circRNA_403658 siRNA 2#. B. LDH activity was determined in 5637 and T24 cells after 48 h transfection with has_circRNA_403658 siRNA 2#. C. ATP concentration was determined in 5637 and T24 cells after 48 h transfection with has_circRNA_403658 siRNA 2#. D. Glucose uptake was determined by Glucose Uptake Colorimetric Assay kit in 5637 and T24 cells after 48 h transfection with has_circRNA_403658 siRNA 2#. E. 5637 and T24 cells were transfected with has_circRNA_403658 siRNA and then treated with oxamate sodium (Oxamate, 80 mM) for 48 h. The cell viability was measured using a Brdu assay. F. 5637 and T24 cells were transfected with has_circRNA_403658 siRNA and then were treated with 6 mM 2-DG for 48 h. Cell viability was measured using a Brdu assay. *P<0.05.