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. 2019 Nov 15;11(11):6826–6837.

Figure 8.

Figure 8

miR-761 is negatively regulated by lncRNA HOXA11-AS in PTC cells. (A) LncRNA HOXA11-AS expression differences between PTC tissues and adjacent non-tumor tissues. (B) An inverse correlation between the levels of miR-761 and HOXA11-AS expression was observed in PTC tissues. (C) TPC-1 that were transfected with HOXA11-AS siRNA or control siRNA were detected by qRT-PCR. HOXA11-AS knockdown significantly increased the expression of miR-761 in TPC-1 cells. (D) 8505C cells that were transfected with HOXA11-AS vector or empty vector were confirmed by qRT-PCR. HOXA11-AS overexpression notably reduced the expression of miR-761 in 8505C cells. Down-regulation of HOXA11-AS inhibited cell proliferation (E), colon formation (F) and cell cycle progression (G) in TPC-1 cells, while overexpression of HOXA11-AS promoted cell proliferation (E), colon formation (F) and cell cycle progression (G) in 8505C cells. n = 6 independent experiments. *P < 0.05.