Skip to main content
. 2019 Nov 15;11(11):6938–6951.

Figure 4.

Figure 4

P4HA2 promotes glycolysis through PGK1 and LDHA. (A) The correlation between the mRNA expression of P4HA2 and glycolysis-related genes based on TCGA cervical cancer dataset. (B) PGK1 and LDHA mRNA expression in Hela cells treated with siP4HA2-1# and siP4HA2-2#, *P<0.05 versus siNC group. (C) PGK1 and LDHA mRNA expression in Hela cells transfected with P4HA2 expression plasmid, *P<0.05. (D and E) Glucose uptake (D) and lactate production (E) were measured in Hela and SiHa cells transfected with P4HA2 expression plasmid and PGK1 siRNA as indicated, *P<0.05 versus siNC group. **P<0.05 versus siPGK1 group. (F and G) Glucose uptake (F) and lactate production (G) were measured in Hela and SiHa cells transfected with P4HA2 plasmid and LDHA siRNA as indicated, *P<0.05 versus siNC group. **P<0.05 versus siLDHA group.