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CCNB1 influences cell cycle progression and migration and invasion of NSCLC cells. Both shRNA interference and upregulation of CCNB1 induce the arrest of cell cycle of NSCLC cells in G2/M (A) and lessen the ability of cloning formation (B) as well as xenograft tumor growth (C). NSCLC: non-small cell lung cancer. shRNA: short hairpin RNA. amplification × 100 under light microscope. *: P<0.05. **: P<0.001.
