Table 1.
Target genes of miR-145 in cancer invasion and metastasis
| MiR-145 | Disease | Target genes | Reference |
|---|---|---|---|
| Downregulated | CRC | PAK4 | [8] |
| TUSC3 | [9] | ||
| p70S6K1 | [10] | ||
| SOX9 | [11] | ||
| MYO6 | [12] | ||
| IRS-1 | [13] | ||
| SIP1 | [14] | ||
| FSCN1 | [15] | ||
| E2F5, BAG4 and FMNL2 | [29] | ||
| BCa | ARF6 | [30] | |
| fascin and JAM-A | [31] | ||
| c-Myc | [32] | ||
| ROCK1 | [33] | ||
| CCNE2 | [34] | ||
| OCT4 | [35] | ||
| MMP11 and Rab27a | [36] | ||
| RTKN | [37] | ||
| MUC1 | [38] | ||
| FSCN1 | [84] | ||
| NSCLC | MUC1 | [48] | |
| NEDD9 | [49] | ||
| FOXM1 | [50] | ||
| MTDH (AEG-1) | [51] | ||
| FSCN1 | [85,86] | ||
| GBM | ADAM17 and EGFR | [56] | |
| ROCK1 | [57] | ||
| ABCG2 | [58] | ||
| CTGF | [59] | ||
| SOX9 and ADD3 | [60] | ||
| OC | MTDH | [68] | |
| RASA1 | [69] | ||
| DNMT3A and HK2 | [70] | ||
| HMGA2 | [71] | ||
| Bladder cancer | PAK1 | [78] | |
| ZEB1/2 and FSCN1 | [79] | ||
| KLF4 | [88] | ||
| CDK6 | [91] | ||
| Sp1 | [92] | ||
| PCa | FSCN1 | [87] | |
| SWAP70 | [93] | ||
| HEF1 (NEDD9 or Cas-L) | [94] | ||
| GC | FSCN1 | [82] | |
| Ets1 | [101] | ||
| SOX9 | [104] | ||
| CTNND1 | [105] | ||
| N-cadherin and ZEB2 | [106] | ||
| Cervical cancer | SIP1 | [107] | |
| MYPT1 | [110] | ||
| OS | VEGF | [112] | |
| MMP16 | [113] | ||
| CDK6 | [114] | ||
| HCC | ADAM17 | [62] | |
| Renal cell carcinoma | ADAM17 | [63] | |
| ESCC | FSCN1 | [80] | |
| LSCC | FSCN1 | [83] | |
| MYO5A | [120] | ||
| Pancreatic cancer | MUC13 | [121] | |
| OSCC | c-Myc and CDK6 | [122] | |
| Endometrial cancer | SOX11 | [123] | |
| Melanoma | NRAS | [124] | |
| ICC | NUAK1 (ARK5) | [125] | |
| Retinoblastoma | ADAM19 | [126] | |
| Thyroid cancer | AKT3 | [130] | |
| Upregulated | esophageal cancer | SMAD5 | [131] |