Disease-free survival and overall survival analyses of hub genes were performed using cBioPortal online platform. RCC patients with CDH11, COL3A1, COL5A1, COL5A2 and COL11A1 alteration showed shorter disease-free survival (P < 0.05) (A-J). Nonetheless, RCC patients with CDH11, COL3A1, COL5A1, COL5A2, COL6A3 and COL11A1 alteration showed shorter overall survival (P < 0.05) (K-T).