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. 2019 Nov 11;11(12):e11170. doi: 10.15252/emmm.201911170

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© 2019 The Authors. Published under the terms of the CC BY 4.0 license

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Change points (also referred to as a significant biomarker change) with 95% CIs of the modeled biomarker trajectories are shown in Fig 1. Hippocampus volume divided by total intracranial volume was added for reference.