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. 2019 Nov 3;11(12):e11115. doi: 10.15252/emmm.201911115

Figure 3. Electrophysiological characterization with 3D‐ and 2D‐cultured hiPSC‐derived CMs.

Figure 3

  • A
    Representative action potentials (APs) measured with sharp microelectrode in EHTs at 1‐Hz pacing.
  • B
    Quantification of AP duration at 90% repolarization (APD90) of Ctrl, HCM, and HCMrep [n = number of EHTs/differentiations; Ctrl (20/8), HCM (13/6), HCMrep (14/5)].
  • C
    Cycle length dependence of APD90 of Ctrl (n = 7/3), HCM (n = 5/2), and HCMrep (n = 3/1).
  • D, E
    Representative traces (D) and quantification (E) of single‐cell patch clamp recordings of L‐type calcium currents [n = number of isolated cardiomyocytes/differentiations; Ctrl (10/3), HCM (20/3), HCMrep (13/3)].
  • F
    Simulated effect of 1.5‐fold ICa,L density in in silico model of human hiPSC‐CM AP and Force.
Data information: Data are expressed as mean ± SEM, one‐way ANOVA with Bonferroni's post‐test.