Table 4.
Characteristics of the autosomal dominant polycystic kidney disease bone biopsy cohort (n = 15)
| Parameter | Value |
|---|---|
| Age (yr) | 29 (10) |
| Sex (% male) | 40 |
| Weight (kg) | 78.5 (13.6) |
| Height (cm) | 174.9 (8.3) |
| Body surface area (m2) | 1.95 (0.19) |
| Body mass index (kg/m2) | 25.7 (4.0) |
| Estimated glomerular filtration rate (ml/min per 1.73 m2) | 106 (20) |
| Erythropoietin (mIU/ml) | 9.7 (5.3) |
| Erythroferrone (ng/ml) | 16.3 (7.3) |
| Hepcidin (ng/mL) | 30.0 (22.4) |
| Iron (mcg/dl) | 96.6 (39.2) |
| Ferritin (ng/ml) | 292.3 (174.3) |
| Hemoglobin (g/dl) | 14.4 (1.8) |
| C-terminal (total) FGF23 (RU/ml) | 113.9 (91.4) |
| Intact FGF23 (pg/ml) | 60.6 (15.8) |
| Bone FGF23/tissue areaa | 1.7 (1.5) |
| Phosphate (mg/dl) | 4.0 (0.5) |
| Calcium (mg/dl) | 9.3 (0.3) |
| Parathyroid hormone (pg/ml) | 27.1 (8.8) |
| 25OH vitamin D3 (ng/ml) | 29.7 (9.3) |
| 1,25(OH)2 vitamin D3 (pg/ml) | 46.0 (13.3) |
| 24,25(OH)2 vitamin D3 (pg/ml) | 2.6 (0.8) |
FGF, fibroblast growth factor.
Data presented as percentages or mean (SD).
a
Bone FGF23/tissue area is defined as the number of osteocytes with positive staining divided by the total tissue area analyzed (mm2).