Table 2.

Dermal Fibroblast Bank to Model Primary Tauopathies

MAPT	Classification	Clinical Presentation	Tau Isoform	Mean AAOa	Mean Disease Durationa	Fibroblasts	Families
A152T	PSP, CBD, FTLD-Tau	bvFTD	4R	57.5	N/A	8	N/A
P301L	FTLD-Tau	bvFTD	4R	52.6	6.7	13	3
S305I	FTLD-Tau/AGD	bvFTD	4R	39	2	2	1
IVS10+16	FTLD-Tau	bvFTD/AD	4R	49.1	10.3	4	1
V337M	FTLD-Tau	bvFTD	3R & 4R	51.5	15.4	4	2
G389R	FTLD-Tau	bvFTD	3R & 4R	39.8	2.5	3	1
R406W	FTLD-Tau	AD	3R & 4R	56.3	11.5	9	2
R406W/R406W	FTLD-Tau	bvFTD	3R & 4R	34	7	1	1
WT	PSP	PSP-S	4R	N/A	N/A	12	N/A
WT	CBD	CBS	4R	N/A	N/A	5	N/A
WT	PSP/CBD mixed	PSP-S/CBS/mixed	4R	N/A	N/A	10	N/A
WT	normal	N/A	N/A	N/A	N/A	69	N/A

AAO, age at onset; bvFTD, behavioral variant frontotemporal dementia; AGD, argyrophilic grain disease; AD, Alzheimer's disease; PSP, progressive supranuclear palsy; CBD, cortical basal degeneration; N/A, not available.

^aData from the AD/FTD Mutation Database presented in years (Cruts et al., 2012).