Table 4.

CRISPR/Cas9-Edited iPSC Lines

Donor ID	Donor Genotype	Isogenic Genotype	Ngn2 Integration	Engineering Methoda	Line Name	Neural Induction
F11362	R406W/WT	WT/WT	no	CRISPR	F11362.1Δ1C11, F11362.1Δ1B6	yes
F11421	R406W/WT	WT/WT	no	CRISPR	F11421.12Δ2A07	yes
F11374	R406W/WT	N/A	yes	TALENs	NF11374.65	yes
160311SBB1	V337M/WT	WT/WT	no	CRISPR	GIH6C1Δ1E11	yes
160311SBB2	V337M/WT	WT/WT	no	CRISPR	GIH7C2Δ2B12, GIH7C2Δ2F02	yes
ND32951A	V337M/WT	WT/WT	no	CRISPR	ND32951A.15Δ1B06, ND32951A.15Δ1C12	yes
GIH36	IVS10+16/WT	WT/WT	no	CRISPR	GIH36C2Δ1D01	yes
F0510	P301L/WT	WT/WT	no	CRISPR	F0510.2Δ2E7, F0510.2Δ2′H1	yes
F0510	P301L/WT	P301L/P301S	no	CRISPR	F0510.2Δ3A11, F0510.2Δ3A9	yes
F0510	P301L/WT	WT/P301S	no	CRISPR	F0510.2Δ3E10, F0510.2Δ4B3, F0510.2Δ4B4	yes
F0510	P301L/WT	P301S/P301S	no	CRISPR	F0510.2Δ3B5	yes
F0510	P301L/WT	N/A	yes	TALENs	NF0510.23, NF0510.12	yes
75.11	S305I/WT	WT/WT	no	CRISPR	75.11-IW1A12	N/A
75.11	S305I/WT	S305I/S305I	no	CRISPR	75.11-IH1B9	N/A
GP1.1	S305S/WT	S305S/S305S	no	CRISPR	GP1.1-SH1G8	N/A
F13505	WT/WT	S305I/WT	no	CRISPR	F13505.1-I1B10	N/A
F13505	WT/WT	S305S/WT	no	CRISPR	F13505.1-S3H5	N/A
F11350	WT/WT	WT/R5H	no	CRISPR	F11350.1.R5HΔ2F06	N/A
F11350	WT/WT	WT/G389R	no	CRISPR	F11350.1.G389R.1C05ΔE03	N/A
F11350	WT/WT	P301L/P301L	no	CRISPR	F11350.1.P301LΔ4A02, F11350.1.P301LΔ4A08	N/A
F12468	WT/WT	N/A	yes	TALENs	NF12468.131	yes
WTC11	WT/WT	N/A	yes	TALENs	NWTC11.G3	yes
WTC11	WT/WT	WT/WT	yes	TALENs/CRISPR	NWTC11.G3.0036	yes
WTC11	WT/WT	V337M/WT	yes	TALENs/CRISPR	NWTC11.G3.0212	yes
WTC11	WT/WT	V337M/V337M	yes	TALENs/CRISPR	NWTC11.G3.3917	yes

^aNgn2 was engineered by TALENs; MAPT mutations/corrections were engineered by CRISPR/Cas9.