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HBV inhibition in vitro measuring with the HepG2 line stably transfected with the NTCP gene.
| Primary data, OD | Mean signal, 3 weals | SD | % INH/AC (ODPos-IDTest)/(ODPos-ODNeg) *100% | p-value | |
|---|---|---|---|---|---|
| Negative control, DMSO 2% | 0.10 | 0.21 | |||
| Title compound, concentration, мкM | 32 | 0.36 | 0.26 | 99.44 | 0.0017 |
| 10 | 9.91 | 0.31 | 79.08 | 0.0134 | |
| 3.2 | 24.50 | 0.76 | 47.97 | 0.0513 | |
| Positive control, DMSO 2%, HBV | 47.00 | 0.34 | |||
