Table 2.
Proteins identified in the the high mobility group box B 2 (HMGB2) Y2H interactome in PC-3 cells.
| Gene (Aliases) | Uniprot Code | N | A | Biological Function | Previous References to Prostate Cancer (PCa) |
|---|---|---|---|---|---|
| C1QBP (GC1QBP, HABP1, SF2P32) | Q07021 | 3 | 1–187 | Control of mitochondrial energetic metabolism. Promotes cell proliferation, migration, and resistance to cell death. [39]. | Highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy [40]. |
| SNAPIN (BLOC1S7, SNAP25BP) | O95295 | 1 | 54–136 | A SNARE-associated protein which binds Snap25 facilitating the vesicular membrane fusion process [41]. | Involved in developing prostate adenocarcinoma in mice [41]. |
| U2AF1 (U2AF35,) | Q01081 | 1 | 31–104 | RNA splicing [42]. | Highly expressed in PCa [43]. |
| UHRF2 (NIRF, RNF107) | Q96PU4 | 1 | 20–169 | UHRF2 encodes a nuclear protein involved in cell-cycle regulation and is an important mediator of E2F1-induced cell death [38]. | Not previously reported |
| ZNF428 (C19orf37) | Q96B54 | 3 | 100–188 | Unknown | Not previously reported |
N: redundancy in clone isolation; A: Sequenced region in clones, Aa relative to ATG.