Table 3.

Top twenty up- and down-regulated proteins from the current study and their function according to the cited literature, in the context of puberty and fertility.

Proteins	log2 Fold Change	Cellular Process	Puberty-Related Function	Reference
DHCR24	3.28	Cholesterol synthesis	Steroidogenesis	Robert K. Murray et al. [41]
FDX1 ADX	3.02	Electron transfer	Steroidogenesis	Miller et al. [42]
HSD3B	2.92	Progesterone synthesis	Steroidogenesis	Miller et al. [43]
HMGCS	2.91	Cholesterol synthesis	Steroidogenesis	Russell et al. [44]
LSS	2.87	Lanosterol synthesis	Steroidogenesis	Christianson et al. [45]
FDXR	2.66	Electron transfer	Steroidogenesis	Miller et al. [42]
TPD52	2.66	Cell cycle regulation	Scrotal circumference association	Meirelles et al. [46]
QPRT	2.13	NAD+ biosynthesis	Antioxidation in steroidogenesis	Aguilera-Méndez, Fernández-Lainez et al. [47]
FASN	2.11	Fatty acid synthesis	Up-regulation of steroidogenesis	Wakil et al. [48]
CYP11A1	2.11	Pregnenolone synthesis	Up-regulation of steroidogenesis	Miller et al. [43]
ACLY	1.75	Citrate synthesis	Up-regulation of steroidogenesis	Guay, Madiraju et al. [49]
IDH3A	1.65	TCA cycle	Up-regulated in old age oocytes	Itami, Kawahara-Miki et al. [50]
Uncharacterized	1.48
NNT	1.37	Electron transport chain	Antioxidant in steroidogenesis	Roucher-Boulez, Mallet-Motak et al. [51]
NDUFC2	1.30	Electron transport chain	Antioxidant in oocyte maturation	Payton, Rispoli et al. [52]
ACAT2	1.29	Acetyl-CoA metabolism	Up-regulation of steroidogenesis	Russell et al. [44]
LONP1	1.26	Mitochondrial activity	Up-regulation of steroidogenesis	Rone, Midzak et al. [53]
AIFM1	1.26	Pro-apoptotic activity	Atresia of antral follicles	Craig, Singh et al. [54]
PTN	1.21	Focal adhesion	Female infertility	Muramatsu, Zou et al. [55]
RBP1	1.20	Retinoic acid signaling	Oocyte maturation	Salhab, Tosca et al. [56]
ASPN	−1.99	Extracellular matrix	Associated with secondary follicle growth Transcription for CL functioning	Aoyama, Shiraishi et al. [57] Meldi, Gaconnet et al. [58]
H3F3A/B	−1.46	Nucleosome assembly	Chromatin remodeling in oocyte maturation	Fournier, Dufort et al. [59]
EIF4B	−1.24	Translation	Translation in oocyte maturation	Ellederová, Cais et al. [60]
SERPINA3	−1.23	Extra cellular matrix	Decreased abundance in 11-days CL Oocyte competence associated	Zalman, Ireland et al. [61] Hamel, Dufort et al. [62]
Uncharacterized PTI	−1.15
TN-X	−1.12	Extracellular matrix	Marker for CL function. Up-regulated in antral follicles and competent oocytes	Dominguez, Cho [63] Cibelli, Iager et al. [64]
ApoC3	−1.09	Cholesterol efflux	Steroidogenesis, down-regulated in cumulus cells of mature oocytes	Shao, Chian et al. [65]
SERPINE2	−1.01	Extracellular matrix	Differential expression in antral follicle and mature oocytes	Bédard, Brûlé et al. [66]
SERPINA3.3	−1.00	Extracellular matrix	Expressed in follicular fluid during oocyte maturation	Ducolomb, González-Márquez et al. [67]
Uncharacterized GSTM	−0.99
H2AFY2	−0.98	Nucleosome assembly	Repressed transcription on meiosis	Wang, Xu et al. [68]
LMCD1	−0.96	Regulation of transcription	Regulation of transcription in spermatogenesis	Griffin, Dunmore et al. [69]
BLT	−0.93	Proteolytic activity	Second maturation of oocyte	Yamane et al. [70]
VCAN	−0.90	Extracellular matrix	Oocyte maturation quality	Dunning, Watson et al. [71]
PRELP	−0.82	Extracellular matrix	Follicular development	Irving-Rodgers and Rodgers et al. [72]
LAMB2	−0.82	Extracellular matrix	Decreases after oocyte maturation	Budna, Celichowski et al. [73]
H1F0	−0.82	Nucleosome assembly	Oocyte maturation	Niu, Zi et al. [74]
FST	−0.82	TGF-β signaling	Progesterone synthesis by suppressing TGF-β signaling Oocyte maturation	Kayani, Glister et al. [75] Adona, Leal et al. [76]
DDX17	−0.80	Transcription	Differential expression in cumulus cells	Assou, Haouzi et al. [77]
FBN1	−0.78	Extracellular matrix	Oocyte quality marker	Powell, Manandhar at al. [78]