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. 2019 Oct 26;11(11):1656. doi: 10.3390/cancers11111656

Figure 3.

Figure 3

Analysis of GPC1-positive-exosome quantification and CellSearch® positive CTC count and clusters according to clinical criteria. Kaplan–Meier curves, with p values (log Rank) for comparison between (A) overall survival (OS) for patients with >20% GPC1-positive exosomes (4 times the median value) and/or with CTC clusters and patient with <20% GPC1-positive exosomes and/or CellSearch® without CTC clusters. (B) Progression-free survival (PFS) for patients with GPC1-positive exosomes and/or CellSearch® positive and GPC1-negative exosomes and/or CellSearch® negative in peripheral blood. (C) Immunofluorescent staining image of captured CTC clusters. Circulating tumor cell clusters captured from a portal vein sample using the CellSearch system. (CK, cytokeratin; PE, phycoerythrin; DAPI, 4′,6-diamidino-2-phenylindole; DAPI stain is purple and CK stain is green, (original magnification ×400)).