Figure 3.

(A) Frequency of increased focal adhesion kinase (FAK) expression at mRNA levels in human cancers. The Cancer Genome Atlas (TCGA) was queried using cbioportal.org to determine the percentage of tumor samples with increased levels of FAK mRNA expression. Search criteria included mRNA expression data (Z-scores for all genes) and tumor datasets with mRNA data. N = number of cancers analysed in the TCGA. (B) Frequency of focal adhesion kinase (FAK) genomic alterations in human cancers. The Cancer Genome Atlas (TCGA) was queried using cbioportal.org to determine the percentage of samples with FAK genomic alterations (mutations, fusions, amplifications, deep deletions, multiples alterations) in different cancers. Search criteria included PTK2 (FAK). N = number of cancers analysed in the TCGA.