Figure 3.

Summary of studies investigating effects of autophagy on therapeutic response in esophageal cancer. Therapeutic interventions that activate autophagy to limit cell death are shown in the yellow circle, while therapies that activate autophagy to promote cell death are shown in the blue circle. Esomeprazole is present in the overlapping space between the two circles as it has been shown to activate autophagy to limit cell death and also promote cell death in a context-dependent manner.