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. 2019 Oct 24;11(11):1635. doi: 10.3390/cancers11111635

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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SLUG overexpression in a quiescent stem-like BTSC line promotes tumor initiation in vivo (see also Figure S8). (A) Brain MRI of mice a year post-xenograft with BT50 CTRL or SLUG_OE cells (dashed lines represent approximate delimitation of enhancing regions) and (B) representative hNucl staining (dashed line represents an approximate tumor delineation). Quantitative analysis and representative close-up hNucl staining of (C) the implanted (right) hemisphere and (D) the contralateral (left) hemisphere (error bars represent SD). (E) Representative images and 2.5× close-up inserts of Iba1 staining in the xenografted and contra-lateral hemispheres of CTRL and SLUG_OE xenografted mice.

SLUG overexpression in a quiescent stem-like BTSC line promotes tumor initiation in vivo (see also Figure S8). (A) Brain MRI of mice a year post-xenograft with BT50 CTRL or SLUG_OE cells (dashed lines represent approximate delimitation of enhancing regions) and (B) representative hNucl staining (dashed line represents an approximate tumor delineation). Quantitative analysis and representative close-up hNucl staining of (C) the implanted (right) hemisphere and (D) the contralateral (left) hemisphere (error bars represent SD). (E) Representative images and 2.5× close-up inserts of Iba1 staining in the xenografted and contra-lateral hemispheres of CTRL and SLUG_OE xenografted mice.