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. 2019 Oct 24;11(11):1635. doi: 10.3390/cancers11111635

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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SLUG-induced transcriptional changes are associated with progenitor-like BTSC precursor state and recurrence (see also Table S2). (A) Revigo visualization of Gene Ontology analysis from RNA sequencing performed on BT50 CTRL and SLUG_OE cells. (B) Heatmap of the 180 differentially expressed genes between BT50 CTRL and SLUG_OE cells in the 57 BTSCs and bar graphs of their respective SLUG_OE, stem-like to progenitor-like (SL/PL), STAT3, and EMT scores (asterisk mark BTSCs from recurrent primary GBMs). (C) Box and whiskers plot (min to max) representing the SLUG_OE score of BTSCs that were derived from primary GBMs compared to those derived from recurrent GBMs (exclusively from de novo GBMs). (D) Scatter plot of SLUG_OE score versus proneural to mesenchymal score.