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. 2019 Nov 19;10(11):941. doi: 10.3390/genes10110941

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Possible regulatory mechanisms of RYBP driving germ cell development. (A) Schematic representation illustrating that RYBP can interact with E2F transcription factor 2 and 3 (E2F2/E2F3) and YY1 transcription factor (YY1) to transcriptionally regulate Cell division cycle 6 (Cdc6) [89]. (B) Schematic representation illustrating that RYBP can interact with E2F6 and YY1 to repress genes such as MaeI, Staq3 and Smc1β [90]. (C) Schematic representation of a possible repression mechanism of RYBP via the E2F6 and DNA methyl transferase 3b (DNMT3B) on Tex11, Ddx4 and MaeI locus by recognizing the methylation mark at the CpG islands [201]. (D) Schematic representation of PCGF6, RYBP and OCT4/POU5F1 acting synergistically in order to activate Kdm2b [71].