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. 2019 Nov 4;11(11):1722. doi: 10.3390/cancers11111722

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immune-related DEGs and construction of the immunoscore model. (a) Consensus matrixes of CRC samples in GEO cohort for each k (k = 2–5), using 1,000 iterations of hierarchical clustering. (b) Kyoto encyclopedia of genes and genomes (KEGG) analysis of immune-related DEGs (Differentially expressed genes). Circular plot of KEGG pathways was enriched, which was related with immune response and tumor proliferation, apoptosis, and migration. (c,d) LASSO coefficient profiles of 13 genes were related with prognostics. The optimal values of the penalty parameter λ were determined by ten-fold cross-validation. (e) Gene Ontology (GO) analysis of the immune-related DEGs. The immunity and cancer biological processes significant were enriched from immune-related DEGs. The processes in the left figure were enriched from up-regulated DEGs. The processes in the right figure were enriched from the up-regulated DEGs.

Immune-related DEGs and construction of the immunoscore model. (a) Consensus matrixes of CRC samples in GEO cohort for each k (k = 2–5), using 1,000 iterations of hierarchical clustering. (b) Kyoto encyclopedia of genes and genomes (KEGG) analysis of immune-related DEGs (Differentially expressed genes). Circular plot of KEGG pathways was enriched, which was related with immune response and tumor proliferation, apoptosis, and migration. (c,d) LASSO coefficient profiles of 13 genes were related with prognostics. The optimal values of the penalty parameter λ were determined by ten-fold cross-validation. (e) Gene Ontology (GO) analysis of the immune-related DEGs. The immunity and cancer biological processes significant were enriched from immune-related DEGs. The processes in the left figure were enriched from up-regulated DEGs. The processes in the right figure were enriched from the up-regulated DEGs.